PRKCB wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PRKCB1 wild-type allele is located in the vicinity of 16p11.2 and is approximately 384 kb in length. This allele, which encodes protein kinase C beta type protein, plays a role in the phosphorylation of many protein substrates in response to activation by calcium or the second messenger diacylglycerol. Certain allelic variants of the PRKCB1 gene are associated with susceptibility to diabetic nephropathy in individuals with either type I or type II diabetes mellitus.

**Synonyms:** - MGC41878 - PKC-beta - PKCB - PRKCB1 - PRKCB2 - Protein Kinase C, Beta 1 Gene - Protein Kinase C, Beta wt Allele - Protein Kinase C, Beta-1 Gene