MDM2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes E3 ubiquitin-protein ligase Mdm2 protein, plays a role in the regulation of transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53 and diminish its tumor suppressor capability.

**Synonyms:** - ACTFS - Double Minute 2, Human Homolog of; p53-Binding Protein Gene - HDM2 - HDMX - LSKB - MDM 2 - MDM2 Oncogene, E3 Ubiquitin Protein Ligase Gene - MDM2 Proto-Oncogene wt Allele - MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase Gene - MDM2 Protooncogene Gene - MDM2, Transformed 3T3 Cell Double Minute 2, p53 Binding Protein (Mouse) Gene - MGC5370 - Mdm2 p53 Binding Protein Homolog (Mouse) Gene - Mdm2, Transformed 3T3 Cell Double Minute 2, p53 Binding Protein Gene - Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog Gene - Mouse Double Minute 2 Homolog Gene - Mouse Double Minute 2, Human Homolog of; p53-Binding Protein Gene - hdm2 - p53-Binding Protein Gene