RIPK1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RIPK1 wild-type allele is located in the vicinity of 6p25.2 and is approximately 37 kb in length. This allele, which encodes receptor-interacting serine/threonine-protein kinase 1 protein, is involved in positive regulation of apoptosis and activation of the transcription factor NF-kappa-B. The RIPK1 gene is down-regulated in mantle cell lymphomas.

**Synonyms:** - FLJ39204 - RIP - RIP1 - Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1 wt Allele