APP wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human APP wild-type allele is located in the vicinity of 22q13.2 and is approximately 290 kb in length. This allele, which encodes amyloid-beta precursor protein, is involved in transcriptional activation and peptide regulation. APP defects can cause Alzheimer's disease and cerebroarterial amyloidosis.

**Synonyms:** - A4 - AAA - ABETA - ABPP - AD1 - APPI - Alzheimer Disease Gene - Amyloid Beta (A4) Precursor Protein (Protease Nexin-II, Alzheimer Disease) wt Allele - Amyloid Beta (A4) Precursor Protein wt Allele - Amyloid of Aging and Alzheimer Disease Gene - CTFgamma - CVAP - PN-II - PN2