STK11 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human STK11 wild-type allele is located in the vicinity of 19p13.3 and is approximately 23 kb in length. This allele, which encodes serine/threonine-protein kinase STK11 protein, is involved in cell cycle arrest at the G1 checkpoint and regulation of cell polarity. Certain allelic variants of the STK11 gene cause Peutz-Jeghers syndrome, a hereditary disease characterized by predisposition to benign and malignant tumors of many organ systems.

**Synonyms:** - LKB1 - LKB1/STK11 Gene - PJS - Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome) Gene - Serine/Threonine Kinase 11 wt Allele