TK1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TK1 wild-type allele is located within 17q23.2-q25.3 and is approximately 13 kb in length. This allele, which encodes thymidine kinase, cytosolic protein, plays a role in phosphorylation of thymidine to form deoxythymidine monophosphate. The TK1 gene is amplified in breast ductal carcinomas and overexpressed in other types of cancer such as colon cancer and thyroid carcinomas.

**Synonyms:** - Thymidine Kinase 1, Soluble wt Allele