POLB wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human POLB wild-type allele is located in the vicinity of 8p11.2 and is approximately 33 kb in length. This allele, which encodes DNA polymerase beta protein, plays a role in DNA base excision repair which entails gap-filling DNA synthesis in a stepwise, distributive fashion. Defects in the POLB gene are associated with certain forms of cancer such as cervical and esophageal cancer.

**Synonyms:** - Polymerase (DNA Directed), Beta wt Allele