CTLA4 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CTLA4 wild-type allele is located within 2q33 and is approximately 6 kb in length. This allele, which encodes cytotoxic T-lymphocyte protein 4, is involved in signal transduction and T-cell regulation. Variant alleles generated from mutations in the gene, have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

**Synonyms:** - ALPS5 - CD - CD152 - CD152 Antigen Gene - CD152 Gene - CELIAC3 - CTLA-4 - CTLA-4 Gene - CTLA4 - CTLA4-TM - Cytotoxic T Lymphocyte-Associated 4 Gene - Cytotoxic T-Lymphocyte Associated Protein 4 wt Allele - Cytotoxic T-Lymphocyte Protein 4 Gene - Cytotoxic T-Lymphocyte-Associated Antigen 4 Gene - Cytotoxic T-Lymphocyte-Associated Protein 4 Gene - Cytotoxic T-Lymphocyte-Associated Serine Esterase-4 Gene - GRD4 - GSE - IDDM12