TNFRSF11B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TNFRSF11B wild-type allele is located in the vicinity of 8q24 and is approximately 29 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member 11B protein, plays a role in bone homeostasis through the mediation of osteoclast apoptosis. Deletions and mutations in the gene are associated with juvenile Paget disease of the bone.

**Synonyms:** - MGC29565 - OCIF - OPG - PDB5 - TNF Receptor Superfamily Member 11b wt Allele - TR1 - Tumor Necrosis Factor Receptor Superfamily, Member 11B (Osteoprotegerin) Gene - Tumor Necrosis Factor Receptor Superfamily, Member 11b Gene