CD40 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CD40 wild-type allele is located within 20q12-q13.2 and is approximately 186 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member 5 protein, is involved in the modulation of T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Deletions in the gene are associated with hyper-IgM immunodeficiency type 3. The gene may play a role in the pathogenesis of Alzheimer's disease.

**Synonyms:** - Bp50 - CD40 Antigen (TNF Receptor Superfamily Member 5) Gene - CD40 Molecule, TNF Receptor Superfamily Member 5 wt Allele - CDW40 - MGC9013 - TNFRSF5 - TNFRSF5 Gene - Tumor Necrosis Factor Receptor Superfamily Member 5 Gene - Tumor Necrosis Factor Receptor Superfamily, Member 5 Gene - p50