FAS wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human FAS wild-type allele is located in the vicinity of 10q24.1 and is approximately 26 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member 6 protein, plays a role in the initiation of the caspase processing cascade that leads to programmed cell death. Mutations in the gene are related to autoimmune lymphoproliferative syndrome type 1A, burn scar-related squamous cell carcinoma and lung cancer susceptibility.

**Synonyms:** - ALPS1A - APO-1 - APT1 - CD95 - FAS1 - FASTM - Fas (TNF Receptor Superfamily, Member 6) Gene - Fas Cell Surface Death Receptor wt Allele - TNFRSF6 - TNFRSF6 Gene - Tumor Necrosis Factor Receptor Superfamily, Member 6 Gene