FCGR2B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human FCGR2B wild-type allele is located within 1q23 and is approximately 15 kb in length. This allele, which encodes low affinity immunoglobulin gamma Fc region receptor II-b protein, is involved in B-cell activation, host defense responses against foreign pathogens, and immune responses. Chromosomal translocation t(1;22)(q22;q11) leads to FCGR2B hyperexpression in a follicular lymphoma.

**Synonyms:** - CD32 - CD32B - FCG2 - Fc Fragment of IgG, Low Affinity IIB, Receptor (CD32) Gene - Fc Fragment of IgG, Low Affinity IIB, Receptor for (CD32) Gene - Fc Fragment of IgG, Low Affinity IIB, Receptor for Gene - Fc Gamma Receptor IIB wt Allele - IGFR2 - RP11-474I16.2