SERPINE1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SERPINE1 wild-type allele is located within 7q21.3-q22 and is approximately 12 kb in length. This allele, which encodes plasminogen activator inhibitor 1 protein, plays a role in preventing the generation of plasmin. Defects in the SERPINE1 gene cause PAI-1 deficiency. Overexpression of this gene is associated with thrombophilia.

**Synonyms:** - PAI - PAI-1 - PAI1 - PLANH1 - Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 Gene - Serpin Family E Member 1 wt Allele