WFDC2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human WFDC2 wild-type allele is located within 20q12-q13.2 and is approximately 12 kb in length. This allele, which encodes WAP four-disulfide core domain protein 2, is putatively involved in the innate immune response of the lung, nasal and oral epithelia. WFDC2 gene expression is up-regulated in certain cancers such as lung adenocarcinomas, pancreatic carcinomas and ovarian serous carcinomas.

**Synonyms:** - EDDM4 - Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core Gene - HE4 - WAP Four-Disulfide Core Domain 2 wt Allele - WAP5 - dJ461P17.6