ADRB2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ADRB2 wild-type allele is located within 5q31-q32 and is approximately 2 kb in length. This allele, which encodes beta-2 adrenergic receptor protein, plays a role in the regulation of both calcium channel complex regulation and adenylyl cyclase activity. A variety of polymorphic forms of the gene are associated with nocturnal asthma, obesity and type 2 diabetes. These variants are frequently generated by point mutations and downregulation of the gene.

**Synonyms:** - ADRB2R - ADRBR - Adrenergic, Beta-2-, Receptor, Surface Gene - Adrenoceptor Beta 2, Surface wt Allele - B2AR - BAR - BETA2AR - Beta-2 Adrenergic Receptor Gene - Beta-2 Adrenoceptor Gene - Beta-Adrenergic Receptor Gene - Catecholamine Receptor Gene