PTN wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PTN wild-type allele is located within 12p12.1-p11.2 and is approximately 14 kb in length. This allele, which encodes pleiotrophin protein, plays a role in mitogenesis for endothelial, epithelial, and fibroblast cells and neurite outgrowth. Further, aberrations of the gene result in allelic variants that are implicated in tumor invasion, angiogenesis, and metastasis.

**Synonyms:** - HARP - HBGF8 - HBNF - NEGF-1 - NEGF1 - Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-Promoting Factor 1) Gene - Pleiotrophin wt Allele