LEFTY2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LEFTY2 wild-type allele is located in the vicinity of 1q42.1 and is approximately 5 kb in length. This allele, which encodes left-right determination factor 2 protein, plays a role in the left-right asymmetry determination of organ systems during development and is also involved in endometrial bleeding regulation. Mutations in this gene produce variant alleles that are associated with left-right axis malformations, particularly in the heart and lungs. Further, certain types of infertility have been associated with aberrant allelic expression in the endometrium.

**Synonyms:** - EBAF - Endometrial Bleeding Associated Factor (Left-Right Determination, Factor A; Transforming Growth Factor Beta Superfamily) Gene - LEFTA - LEFTY2 Transforming Growth Factor, Beta-4 Gene - LEFTY2, Mouse, Homolog of Gene - LEFTYA - Left-Right Determination Factor 2 wt Allele - Left-Right Determination, Factor A Gene - MGC46222 - PSEC0024 - TGF-Beta 4 Gene - TGFB4 - Transforming Growth Factor, Beta-4 (Endometrial Bleeding-Associated Factor; LEFTY A) Gene