FGFR2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human FGFR2 wild-type allele is located within 10q26 and is approximately 875 kb in length. This allele, which encodes fibroblast growth factor receptor 2 protein, plays a role in mitogenesis and differentiation by mediating the binding interactions of keratinocyte growth factor. Mutations in the gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.

**Synonyms:** - BBDS - BEK - BEK Fibroblast Growth Factor Receptor Gene - BEK, Mouse, Homology of Gene - BFR-1 - Bacteria-Expressed Kinase Gene - CD332 - CEK3 - CFD1 - Craniofacial Dysostosis Gene - Crouzon Syndrome Gene - ECT1 - FGFR2 - Fibroblast Growth Factor Receptor 2 wt Allele - Fibroblast Growth Factor Receptor BEK Gene - JWS - Jackson-Weiss Syndrome Gene - K-SAM - KGFR Gene - KSAM-1 - Keratinocyte Growth Factor Receptor Gene - Pfeiffer Syndrome Gene - Protein Tyrosine Kinase, Receptor-Like, 14 Gene - TK14 - TK25