Ganciclovir

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.

**Synonyms:** - 2'-Nor-2'-deoxyguanosine - 2'NDG - 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one - 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine - Cymevan - DHPG - GANCICLOVIR - GCV - Nordeoxyguanosine - Nordeoxyguanosine - Virgan - ganciclovir