NR3C1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NR3C1 wild-type allele is located in the vicinity of 5q31.3 and is approximately 125 kb in length. This allele, which encodes glucocorticoid receptor protein, is involved in transcriptional regulation that affects a variety of processes such as blood glucose concentration, protein/fat metabolism, inflammatory responses, cellular proliferation, and differentiation. Mutations in the gene are a primary cause of glucocorticoid resistance, or cortisol resistance.

**Synonyms:** - GCR - GR - GRL - Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) wt Allele