PPARG wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PPARG wild-type allele is located in the vicinity of 3p25 and is approximately 146 kb in length. This allele, which encodes peroxisome proliferator-activated receptor gamma protein, plays a role in adipocyte differentiation. The gene has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Mutations in the gene can lead to type 2 insulin-resistant diabetes, hypertension, obesity, colon cancer, familial partial lipodystrophy type 3 and carotid intimal medial thickness 1.

**Synonyms:** - CIMT1 - GLM1 - HUMPPARG - NR1C3 - PPARG - PPARG1 - PPARG2 - PPARgamma - Peroxisome Proliferative Activated Receptor, Gamma Gene - Peroxisome Proliferator-Activated Receptor Gamma wt Allele