PTCH1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PTCH1 wild-type allele is located in the vicinity of 9q22.3 and is approximately 65 kb in length. This allele, which encodes protein patched homolog 1 protein, plays a role in embryonic structure formation and tumor suppression. Mutations of the gene have been associated with several cancers and disease phenotypes, including: nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, and holoprosencephaly.

**Synonyms:** - BCNS - BCNS1 - HPE7 - NBCCS - PTC - PTC1 - PTCH - Patched (Drosophila) Homolog Gene - Patched 1 wt Allele - Patched Homolog 1 (Drosophila) Gene - Patched Homolog 1 Gene - Patched, Drosophila, Homolog of, 1 Gene