Recombinant Human CD4 Immunoglobulin

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** An immunoconjugate of recombinant CD4 antigen (rCD4) covalently linked to an immunoglobulin G heavy chain with activity against human immunodeficiency virus (HIV). Recombinant CD4 antigen competitively binds to the envelope glycoprotein gp120 of HIV, prevents the attachment of gp120 to CD4 on T lymphocytes, and acts as an HIV fusion inhibitor; the immunoglobulin G portion extends the length of time that rCD4 stays in the body.

**Synonyms:** - rCD4-IgG