CD3E wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CD3E wild-type allele is located within 11q23 and is approximately 11 kb in length. This allele, which encodes T-cell surface glycoprotein CD3 epsilon chain protein, is involved in signal transduction essential for T cell receptor signaling and synapse formation. Certain allelic variants of the CD3E gene are associated with T cell immunodeficiency.

**Synonyms:** - CD3-Epsilon Gene - CD3E Antigen, Epsilon Polypeptide (TiT3 Complex) wt Allele - T-Cell Antigen Receptor Complex, Epsilon Subunit of T3 Gene - T-Cell Surface Antigen T3/LEU-4 Epsilon Chain Gene - T-Cell Surface Glycoprotein CD3 Epsilon Chain Gene - T3E - TCRE