CD247 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CD247 wild-type allele is located within 1q22-q23 and is approximately 88 kb in length. This allele, which encodes T-cell surface glycoprotein CD3 zeta chain protein, is involved in coupling antigen recognition to several intracellular signal transduction pathways in T cells. Both heritable and somatic defects in the CD247 gene are associated with T cell immunodeficiency.

**Synonyms:** - CD247 Molecule wt Allele - CD3Z - T3Z - TCRZ