GCLC wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GCLC wild-type allele is located within 6p12 and is approximately 48 kb in length. This allele, which encodes glutamate-cysteine ligase catalytic subunit protein, is involved in the biosynthesis of glutathione. Heritable defects in the GCLC gene are associated with hemolytic anemia (due to deficiency of gamma-glutamylcysteine synthetase) and susceptibility to myocardial infarction.

**Synonyms:** - GCL - GCS - GLCL - GLCLC - Glutamate-Cysteine Ligase, Catalytic Subunit wt Allele