IL12RB2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human IL12RB2 wild-type allele is located within 1p31.3-p31.2 and is approximately 90 kb in length. This allele, which encodes interleukin-12 receptor beta-2 chain protein, plays a role in the proliferation of both T cells and natural killer cells. It is also involved in Th1 cell differentiation. Up-regulation of the IL12RB2 gene is associated with certain infectious diseases such as Crohn's disease and leprosy.

**Synonyms:** - IL-12RB2 - Interleukin 12 Receptor, Beta 2 wt Allele - Interleukin 12 Receptor, Beta-2 Gene - RP11-102M16.1