BRCA2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human BRCA2 wild-type allele is located in the vicinity of 13q12.3 and is approximately 84 kb in length. This allele, which encodes breast cancer type 2 susceptibility protein, is involved in double-stranded DNA break repair, homologous recombination and transcriptional regulation. Certain allelic variants of the BRCA2 gene are associated with early-onset breast cancer, prostate cancer and Fanconi anemia.

**Synonyms:** - BRCA2, DNA Repair Associated wt Allele - BRCC2 - BROVCA2 - Breast Cancer 2 Gene - Breast Cancer 2, Early Onset wt Allele - Breast Cancer Type 2 Susceptibility Gene - FACD - FAD - FAD1 - FANCD - FANCD1 - GLM3 - Hereditary Breast Cancer 2 Gene - PNCA2 - XRCC11