HMGA1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human HMGA1 wild-type allele is located within 6p21 and is approximately 9 kb in length. This allele, which encodes high mobility group protein HMG-I/HMG-Y, is involved in chromatin remodeling, DNA-dependent transcriptional regulation and inhibition of tumor suppressor p53 protein-dependent apoptosis. The HMGA1 gene is overexpressed in certain types of cancer including breast carcinoma, colorectal cancer, non-small-cell lung carcinoma, epithelial ovarian carcinoma and thyroid cancer.

**Synonyms:** - HMG-I(Y) Gene - HMG-R Gene - HMG1A1 - HMGIY Gene - High Mobility Group AT-Hook 1 wt Allele - High Mobility Group Protein HMG-I/HMG-Y Gene - High Mobility Group Protein HMGI-Y Gene - High Mobility Group Protein Isoforms I and Y Gene - High-Mobility Group (Nonhistone Chromosomal) Protein Isoforms I And Y Gene - MGC12816 Gene - MGC4242 Gene - MGC4854 Gene - Nonhistone Chromosomal High-Mobility Group Protein HMG-I/HMG-Y Gene