RB1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RB1 wild-type allele is located in the vicinity of 13q14.2 and is approximately 178 kb in length. This allele, which encodes retinoblastoma-associated protein, is involved in the modulation of cellular proliferation. Mutation or deletion of the wild-type allele is a factor in the childhood onset of hereditary retinal cancer.

**Synonyms:** - OSRC - PPP1R130 - Protein Phosphatase 1, Regulatory Subunit 130 Gene - RB - RB Transcriptional Corepressor 1 wt Allele - Retinoblastoma 1 (Including Osteosarcoma) Gene - Retinoblastoma 1 Gene - p105-Rb - p110-RB1 - pRb - pp110