CISH wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CISH wild-type allele is located in the vicinity of 3p21.3 and is approximately 5 kb in length. This allele, which encodes the cytokine inducible SH2-containing protein, is involved in the suppression of cytokine signaling. Deletion of the CISH wild-type allele may play a role in the pathogenesis of renal cell carcinomas and of lung cancer.

**Synonyms:** - CIS Gene - CIS-1 Gene - Cytokine-Inducible Inhibitor of Signaling Type 1B Gene - Cytokine-Inducible SH2-Containing Protein wt Allele - G18 Gene - SOCS Gene - Suppressor of Cytokine Signaling Gene