18F-Fluoromisonidazole

**Semantic type:** Pharmacologic Substance

**Definition:** A radiofluorinated 2-nitroimidazole derivate with hypoxia-specific tracer activity. Misonidazole is reduced under hypoxic conditions and in reduced form covalently binds to macromolecules in hypoxic cells. 18F (fluorine-18) radiofluorination of misonidazole to form 18F-fluoromisonidazole allows radioisotopic imaging of reduced misonidazole bound to macromolecules in hypoxic cells.

**Synonyms:** - 18F-MISO - 18F-MISO - 18F-Misonidazole - 18F-fluoromisonidazole - FLUOROMISONIDAZOLE F-18 - FMISO - FMISO