Atiprimod

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.

**Synonyms:** - ATIPRIMOD - Azaspirane SK&F106615 - N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine - SK&F106615 - SK&F106615 - atiprimod - azaspirane