NTRK3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NTRK3 wild-type allele is located within 15q25 and is approximately 380 kb in length. This allele, which encodes NT-3 growth factor receptor protein, is involved in MAPK signal transduction and cellular differentiation. The allele may also play a role in the development of proprioceptive neurons. Mutations in the gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

**Synonyms:** - NTRK3 - Neurotrophic Receptor Tyrosine Kinase 3 wt Allele - Neurotrophic Tyrosine Kinase Receptor 3 Gene - Neurotrophic Tyrosine Kinase, Receptor, Type 3 Gene - TRKC