PDGFRB wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PDGFRB wild-type allele is located within 5q31-q32 and is approximately 42 kb in length. This allele, which encodes beta platelet-derived growth factor receptor protein, is involved in mitogenesis for cells of mesenchymal origin. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

**Synonyms:** - CD140B - IBGC4 - IMF1 - JTK12 - KOGS - PDGF-R-Beta - PDGFR - PDGFR Beta - PDGFR1 - PDGFRB - PENTT - Platelet Derived Growth Factor Receptor Beta wt Allele - Platelet-Derived Growth Factor Receptor, Beta Gene - Platelet-Derived Growth Factor Receptor, Beta Polypeptide Gene