RET wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RET wild-type allele is located in the vicinity of 10q11.2 and is approximately 53 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase receptor ret protein, plays a role in neural crest development. Mutations in the gene are associated with multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.

**Synonyms:** - CDHF12 - Gene Rearranged During Transfection - HSCR1 - MEN2A - MEN2B - MTC1 - PTC - RET - RET Proto-Oncogene (Multiple Endocrine Neoplasia and Medullary Thyroid Carcinoma 1, Hirschsprung Disease) wt Allele - RET51 - Rearranged During Transfection Protooncogene Gene