WAS wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human WAS wild-type allele is located within Xp11.4-p11.21 and is approximately 8 kb in length. This allele, which encodes actin nucleation-promoting factor WAS protein, plays a role in actin cytoskeletal organization. Mutations in this gene are the cause of Wiskott-Aldrich syndrome an X-linked disease characterized by eczema, immune deficiencies and thrombocytopenia.

**Synonyms:** - IMD2 - SCNX - THC - THC1 - Thrombocytopenia 1 (X-Linked) Gene - WASP - WASP Actin Nucleation Promoting Factor wt Allele - WASPA - Wiskott-Aldrich Syndrome (Eczema-Thrombocytopenia) Gene - Wiskott-Aldrich Syndrome Gene