TP53 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TP53 wild-type allele is located in the vicinity of 17p13.1 and is approximately 19 kb in length. This allele, which encodes cellular tumor antigen p53 protein, plays a role in cell cycle regulation during the G0/G1transition. Alterations of the TP53 gene occur as both somatic and germline mutations in human malignancies in select cancer-prone families with Li-Fraumeni syndrome.

**Synonyms:** - BCC7 - FLJ92943 - LFS1 - P53 - TP53 - TRP53 - Tumor Protein P53 (Li-Fraumeni Syndrome) wt Allele - Tumor Protein p53 Gene - p53 - p53 gene - p53 wild type