NUP214 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NUP214 wild-type allele is located in the vicinity of 9q34.1 and is approximately 108 kb in length. This allele, which encodes nuclear pore complex protein Nup214, plays a role in the regulation of nucleocytoplasmic transport and receptor-mediated nuclear import. The 3 prime portion of the gene can form a fusion construct with the DEK gene on chromosome 6 in a t(6,9) translocation. The translocation is associated with acute myeloid leukemia and myelodysplastic syndrome.

**Synonyms:** - CAIN - CAN - CAN Protein, Putative Oncogene - D9S46E - IIAE9 - KIAA0023 - N214 - NUP214 - Nucleoporin 214kDa Gene - Nucleoporin, 214-kD Gene