NUP98 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NUP98 wild-type allele is located in the vicinity of 11p15.4 and is approximately 123 kb in length. This allele, which encodes nuclear pore complex protein Nup98-Nup96 protein, is involved in the regulation of the nuclear pore complex and protein docking. Translocations in several myeloid leukemias contain NUP98 fused to other genes; t(7;11)(p15;p15) generates N-terminal NUP98 fused in-frame to HOXA9. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.

**Synonyms:** - ADAR2 - ADIR2 - NUP196 - NUP96 - Nucleoporin 96 Gene - Nucleoporin 98 Gene - Nucleoporin 98 and 96 Precursor wt Allele - Nucleoporin 98kDa Gene - Nucleoporin, 98-kD Gene - Nup98-96 - Nup98-Nup96