CYP1A1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP1A1 wild-type allele is located within 15q22-q24 and is approximately 6 kb in length. This allele, which encodes cytochrome P450 1A1 protein, plays a role in the metabolism of polyaromatic hydrocarbons (PAHs). Individuals with a high-inducibility phenotype, who exhibit elevated CYP1A1 gene expression in response to PAHs, may be at greater risk for cigarette smoke-induced bronchogenic carcinoma.

**Synonyms:** - AHH - AHRR - CP11 - CY11 - CYP1 - Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 wt Allele - P1-450 - P450-C - P450DX - P450D\X