TYROBP wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TYROBP wild-type allele is located in the vicinity of 19q13.1 and is approximately 4 kb in length. This allele, which encodes TYRO protein tyrosine kinase-binding protein, plays a role in the modulation of killer cell activation. Mutation of the gene is associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy.

**Synonyms:** - DAP12 - KARAP - PLO-SL - PLOSL - TYRO Protein Tyrosine Kinase Binding Protein wt Allele - TYROBP