CYP3A4 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP3A4 wild-type allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, which encodes cytochrome P450 3A4 protein, plays a role in the oxidation of steroids, drugs, carcinogens and other xenobiotics. CYP3A4 gene dysfunction is associated with both lung cancer and epipodophyllotoxin-induced leukemogenesis.

**Synonyms:** - CP33 - CP34 - CYP3 - CYP3A - CYP3A3 - CYPIIIA4 - Cytochrome P450 Family 3 Subfamily A Member 4 wt Allele - Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene - Cytochrome P450, Family IIIA, Member 4 Gene - HLP - NF-25 - P450, FAMILY III Gene - P450-III, Steroid Inducible Gene - P450-III, Steroid-Inducible Gene - P450-PCN1 - P450C3 - P450PCN1