KRIT1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human KRIT1 wild-type allele is located within 7q21-q22 and is approximately 102 kb in length. This allele, which encodes Krev interaction trapped protein 1, may play a role in integrin signaling modulation. Mutations in the gene, which encode for products that terminate prematurely, are a factor in familial cerebral cavernous malformations.

**Synonyms:** - CAM - CCM1 - Cerebral Cavernous Malformations 1 Gene - KRIT1, Ankyrin Repeat Containing wt Allele