CBFB wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CBFB wild-type allele is located in the vicinity of 16q22.1 and is approximately 72 kb in length. This allele, which encodes core-binding factor subunit beta protein, plays a role in the mediation of transcription. Acute myeloid leukemia of the M4Eo subtype is linked to the occurrence of a chromosomal inversion inv(16)(p13;q22), which fuses this gene to the MYH11 gene.

**Synonyms:** - CBF-Beta Gene - CBFB - Core-Binding Factor Subunit Beta wt Allele - Core-Binding Factor, Beta Subunit Gene - PEBP2B - Polyomavirus Enhancer Binding Protein 2, Beta Subunit Gene