KRAS wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human KRAS wild-type allele is located in the vicinity of 12p12.1 and is approximately 45 kb in length. This allele, which encodes GTPase KRas protein, plays a role in the modulation of both cellular proliferation and differentiation. Mutations in the gene are associated with juvenile myelomonocytic leukemia, Noonan syndrome 3 and cardiofaciocutaneous syndrome.

**Synonyms:** - C-K-RAS - C-K-Ras Oncogene - CFC2 - Cellular c-Ki-Ras2 Proto-Oncogene - K-RAS2A - K-RAS2B - K-RAS4A - K-RAS4B - K-Ras 2A - KI-RAS - KRAS1 - KRAS2 - KRas Proto-Oncogene, GTPase wt Allele - Kirsten Rat Sarcoma Viral Oncogene Homolog Gene - NS - NS3 - PR310 - RALD - RASK2 - v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog Gene - v-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Gene