SMAD2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SMAD2 wild-type allele is located in the vicinity of 18q21.1 and is approximately 93 kb in length. This allele, which encodes mothers against decapentaplegic homolog 2 protein, plays a role in the potentiation of transforming growth factor-beta signaling; and thus, regulates cellular proliferation, apoptosis, and differentiation.

**Synonyms:** - JV18 - JV18-1 - MADH2 - MADH2 Gene - MADR2 - SMAD, Mothers Against DPP Homolog 2 (Drosophila) wt Allele