ERG wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ERG wild-type allele is located in the vicinity of 21q22.3 and is approximately 280 kb in length. This allele, which encodes transcriptional regulator ERG protein, is involved in both the regulation of RNA polymerase II-directed transcription and the modification of local chromatin structure. Acute myelogenous leukemia of the subtype M2 is linked to the chromosomal translocation t(8;21)(q22;q22), which involves this gene and the EWSR1 gene. Human myeloid leukemia is linked to the chromosomal translocation t(16;21)(p11;q22) of this gene with the FUS gene.

**Synonyms:** - ERG, ETS Transcription Factor Gene - ETS Transcription Factor ERG wt Allele - Early Response Gene - Ets-Related Gene - Transcriptional Regulator ERG (Transforming Protein ERG) Gene - erg-3 - p55 - v-ETS Erythroblastosis Virus E26 Oncogene Like (Avian) Gene - v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog Gene - v-Ets Avian Erythroblastosis Virus E26 Oncogene Related Gene - v-Ets Erythroblastosis Virus E26 Oncogene Like Gene