MECOM wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human MECOM wild-type allele is located in the vicinity of 3q26.2 and is approximately 580 kb in length. This allele, which encodes histone-lysine N-methyltransferase MECOM protein, is involved in DNA binding, transcription factor activity and histone methylation. Mutation of the gene is associated with radioulnar synostosis with amegakaryocytic thrombocytopenia-2. Chromosomal translocations involving this gene are associated with leukemogenesis.

**Synonyms:** - EVI1 - Ecotropic Viral Integration Site 1 Gene - KMT8E - MDS1 - MDS1 and EVI1 Complex Locus wt Allele - MDS1-EVI1 - MGC163392 - MGC97004 - Myelodysplasia Syndrome 1 Gene - Myeloid Leukemia-Associated Gene EVI1, Mouse, Homolog of Gene - PR Domain 3 Gene - PRDM3 - RUSAT2