NF1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NF1 wild type allele is located in the vicinity of 17p11.2 and is approximately 279 kb in length. This allele, which encodes neurofibromin protein, may be involved in the attenuation of Ras signal pathway. Mutations in this allele are associated with type I neurofibromatosis, juvenile myelomonocytic leukemia and Watson syndrome.

**Synonyms:** - NFNS - Neurofibromatosis Gene - Neurofibromin 1 (Neurofibromatosis, Von Recklinghausen Disease, Watson Disease) Gene - Neurofibromin 1 wt Allele - VRNF - Von Recklinghausen Disease Gene - WSS - Watson Disease Gene